Embryo researchers make promisingunique wristbands find

A Guide To Upcoming Local Music Festivals And Events Honestly I never thought of it until recently. It has taken me 33 years to realize its OK to say you"re an artist. I don"t know why but I always felt timid to talk about my art or even admit I drew or painted something... in the last three years I"ve come to terms with my talents and am totally embracing it and having such a fun time in the process. I used to always feel that the art I created was worthless and hated compliments. Wish I could have... stayed positive. Speaking of beer, drinks are not exactly dirt cheap at Off Broadway, but they are pretty reasonable for a respected St. Louis music venue. Stag and Pabst Blue Ribbon beers are $3 most nights, nicer beers might be a little more, and mixed drinks are usually closer to $5. Occasionally, they will offer a special, such as dollar PBRs, but it"s not routine. Kick off fall and bid farewell to summer at an outdoor festival. The Labor Day Spectacular at Wintergreen Resort includes an arts and craft show, live music and more. The Taste of the Mountains Main Street Festival in Madison offers old-fashioned family fun for all ages. If you are planning to visit the US as a part of the music travels, bet you wouldn"t want to miss the Ozzfest. This is the biggest as well as the most influential musical event of the world. Heavy metal is the language that is followed in the Ozzfest. If you are a fan of Ozzy and Black Sabbath, then do not forget to drag yourself to the closing ceremony of this musical fest. This is because those usually perform on the finishing day. Do keep in mind that the dates of this exclusive heavy metal festival wristbands fall in the month of August; it is organized every year. SET THE DATE: The date of your event will depend on a couple of things. If it is a birthday or anniversary event wristbands then you are controlled by the date. If it is just a party the date may be controlled by the locations availability. If the event is at your home then you are in control. Pick what ever date you want. I have even gone as far as check with some guests a couple weeks in advance to make sure they are available on a certain date. I really like success! Fishing sport wristbands is another popular pastime in Lorne. Beach fishing can be good but most anglers seem to prefer the Lorne pier where you can catch just about anything. Whiting and Flathead are a common catch and in winter you can get on to a school of Snapper. Squid can also be caught by jigging at the end of the pier. If you don"t have any luck there is no need to worry because the local fishing co-op is right near the pier and they do very good fish and chips. Before making plans, decide whether you want to spend the weekend working, playing or relaxing. Do you plan to entertain, educate or gather together with family and friends? Wherever your Labor Day weekend plans take you, be careful on the road. Holiday traffic will be heavy and there"s construction around town and across the state.
A nurse takes care of a newborn baby at Gansu Provincial Maternity and Childcare Hospital in Lanzhou. [Photo/Xinhua]

Shanghai researchers have discovered a method to detect and correct abnormalities in nonhuman mammal eggs to prevent certain hereditary diseases in offspring.

Screening for some rare diseases currently relies on gene sequencing, but in some cases, the embryo"s genes are normal but diseases develop later in the fetus, researchers said.

Such cases mainly arise during cell development, or epigenesis.

"In other words, some switches in the genes go wrong," said Sun Yun, a leading researcher on the team and director of the reproductive medicine center at Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine.

In lab tests on mice, Sun"s team was able to identify certain abnormalities in eggs and found that they can be edited and corrected to a normal state through gene editing technology.

A paper about the team"s four years of research was published in the United States-based Journal of Proceedings of the National Academy of Sciences on May 14.

Sun, who chairs the reproductive medicine branch of the Shanghai Medical Association, said the next step is to see if the detection method works for humans, and to block the inheritance of abnormal genes from a mother"s egg and make corrections before a baby"s birth.

"If the research is to be applied clinically one day, the targets include mothers whose first child developed a rare disease," Sun said.

Another researcher on the team, Du Yanzhi, who is also director of the genetic lab of the Reproductive Medicine Center of Renji Hospital, said the study first focused on rare disorders, such as Angelman syndrome, whose main clinical manifestations include learning and behavioral difficulties.

But the study may also bring insights into new therapies for other conditions, such as autism, researchers said.

"There are studies showing that only 5 percent of autistic people have problems in their gene sequencing, so probably many of the rest get the disease as a result of epigenetic changes in the genes of the fathers" or mothers" reproductive cells," Sun said.

They looked at eggs rather than sperm in the research, because an egg contributes much more to the process when an embryo is formed, researchers said.

"Sperm only provides 23 chromosomes with genetic information, and an egg does the same. But the cytoplasm and mitochondria of an egg also carry a lot of genetic information to the offspring," Sun said.

The technique, if applied clinically, may also be useful for in vitro fertilization, to check for risks of epigenetic changes in the reproductive cells, Sun said.

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